Codes and coverage

Codes and coverage

Supporting patient access

BMS Access Support® may help support patient access by conducting benefits reviews and offering prior authorization and appeals process assistance for enrolled patients. Additionally, the information below provides product-specific billing and diagnosis codes, reimbursement and coding guides, distribution information, and additional coverage support offerings. To view available coding and coverage information, please select your patient’s prescribed medication.

Additional eligibility criteria and terms may apply. Bristol Myers Squibb and its agents make no guarantee regarding reimbursement for any service or item.

Read more about our coverage support offerings
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Benefits Reviews

  • Once a patient is enrolled in BMS Access Support, we can review their insurance coverage and provide a summary of benefits within approximately 24 hours*
  • A benefits review may help determine whether or not a medication is covered, if a PA is required, and estimated patient out-of-pocket costs

*BMS Access Support Data - Benefits review. Accessed August 2022.

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Prior Authorization (PA) and Appeals Assistance

  • Use the BMS Access Map to identify plan-specific PA requirements
  • View our forms and resources page for helpful support tools, including appeals letter templates and medical necessity letters

Annual Reverification

  • Reverification of benefits is available upon request to confirm a patient’s benefits for the new year
  • Connect with your local Access and Reimbursement Manager for more information
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The accurate completion of reimbursement- or coverage-related documentation is the responsibility of the healthcare provider and patient. Bristol Myers Squibb and its agents make no guarantee regarding reimbursement for any service or item.

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Reimbursement and Coding Guide
for OPDIVO QVANTIG

Select Your Patient’s Condition

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Healthcare Common Procedure Coding System (HCPCS) Codes1

Issued by CMS

Providers and suppliers are required to report the JW modifier on Part B drug claims for unused drugs and biologicals that are appropriately discarded. Also, providers and suppliers must document the amount of discarded drugs or biologicals in Medicare beneficiaries’ medical records.2

Providers and suppliers are required to report the JZ modifier to attest if there were no discarded amounts of drugs and biologicals.3

J3590 Copy Unclassified biologics
J3490 Copy Unclassified drugs
J9999 Copy Not otherwise classified anti-neoplastic drugs
C9399 Copy Unclassified drugs or biologicals (hospital outpatient use only)

Depending on payer preferences for billing and coding, the required miscellaneous J-code and billing unit conversion for claim submission may vary. Therefore, the provider should confirm preference with the payer prior to submitting. Please contact the payer or BMS Access Support® for additional information on coding and billing units.

Revenue Codes (for Hospital Use)4

0636 Copy Drugs requiring detailed coding
0250 Copy Pharmacy (General)
0331 Copy Chemotherapy administration, injected

Current Procedural Terminology (CPT)5,†

96401 Copy Chemotherapy administration, SC or intramuscular; non-hormonal anti-neoplastic

National Drug Codes (NDC)6

Issued by the FDA

Note: Payers require the submission of the 11-digit NDC on healthcare claim forms. Please use the 11-digit codes shown here.

00003-6120-01 Copy Individually packaged single-dose vials providing 600 mg of nivolumab and 10,000 units of hyaluronidase per 5 mL

International Classification of Diseases, Tenth Revision, Clinical Modification Diagnosis Codes (ICD-10-CM)7

C18 Copy Malignant neoplasm of colon
C18.0 Copy Malignant neoplasm of cecum
C18.1 Copy Malignant neoplasm of appendix
C18.2 Copy Malignant neoplasm of ascending colon
C18.3 Copy Malignant neoplasm of hepatic flexure
C18.4 Copy Malignant neoplasm of transverse colon
C18.5 Copy Malignant neoplasm of splenic flexure
C18.6 Copy Malignant neoplasm of descending colon
C18.7 Copy Malignant neoplasm of sigmoid colon
C18.8 Copy Malignant neoplasm of overlapping sites of colon
C18.9 Copy Malignant neoplasm of colon, unspecified
C19 Copy Malignant neoplasm of rectosigmoid junction
C20 Copy Malignant neoplasm of rectum

International Classification of Diseases, Tenth Revision, Clinical Modification Diagnosis Codes (ICD-10-CM)7

C15 Copy Malignant neoplasm of esophagus
C15.3 Copy Malignant neoplasm of upper third of esophagus
C15.4 Copy Malignant neoplasm of middle third of esophagus
C15.5 Copy Malignant neoplasm of lower third of esophagus
C15.8 Copy Malignant neoplasm of overlapping sites of esophagus
C15.9 Copy Malignant neoplasm of esophagus, unspecified
C16 Copy Malignant neoplasm of stomach
16.0 Copy Malignant neoplasm of cardia
Malignant neoplasm of cardiac orifice
Malignant neoplasm of cardio-esophageal junction
Malignant neoplasm of esophagus and stomach
Malignant neoplasm of gastro-esophageal junction

International Classification of Diseases, Tenth Revision, Clinical Modification Diagnosis Codes (ICD-10-CM)7

C15 Copy Malignant neoplasm of esophagus
C15.3 Copy Malignant neoplasm of upper third of esophagus
C15.4 Copy Malignant neoplasm of middle third of esophagus
C15.5 Copy Malignant neoplasm of lower third of esophagus
C15.8 Copy Malignant neoplasm of overlapping sites of esophagus
C15.9 Copy Malignant neoplasm of esophagus, unspecified
C16 Copy Malignant neoplasm of stomach
C16.0 Copy Malignant neoplasm of cardia
Malignant neoplasm of cardiac orifice
Malignant neoplasm of cardio-esophageal junction
Malignant neoplasm of esophagus and stomach
Malignant neoplasm of gastro-esophageal junction
C16.1 Copy Malignant neoplasm of fundus of stomach
C16.2 Copy Malignant neoplasm of body of stomach
C16.3 Copy Malignant neoplasm of pyloric antrum
C16.4 Copy Malignant neoplasm of pylorus
C16.5 Copy Malignant neoplasm of lesser curvature of stomach, unspecified
C16.6 Copy Malignant neoplasm of greater curvature of stomach, unspecified
C16.8 Copy Malignant neoplasm of overlapping sites of stomach
C16.9 Copy Malignant neoplasm of stomach, unspecified

International Classification of Diseases, Tenth Revision, Clinical Modification Diagnosis Codes (ICD-10-CM)7

C22 Copy Malignant neoplasm of liver and intrahepatic bile ducts
C22.0 Copy Liver cell carcinoma (hepatocellular carcinoma, hepatoma)
C22.8 Copy Malignant neoplasm of liver, primary, unspecified as to type

International Classification of Diseases, Tenth Revision, Clinical Modification Diagnosis Codes (ICD-10-CM)7

C21 Copy Malignant neoplasm of anus and anal canal
C21.0 Copy Malignant neoplasm of anus, unspecified
C21.1 Copy Malignant neoplasm of anal canal
C43 Copy Malignant melanoma of skin
C43.0 Copy Malignant melanoma of lip
C43.1 Copy Malignant melanoma of eyelid, including canthus
C43.10 Copy Malignant melanoma of unspecified eyelid, including canthus
C43.11 Copy Malignant melanoma of right eyelid, including canthus
C43.111 Copy Malignant melanoma of right upper eyelid, including canthus
C43.112 Copy Malignant melanoma of right lower eyelid, including canthus
C43.12 Copy Malignant melanoma of left eyelid, including canthus
C43.121 Copy Malignant melanoma of left upper eyelid, including canthus
C43.122 Copy Malignant melanoma of left lower eyelid, including canthus
C43.2 Copy Malignant melanoma of ear and external auricular canal
C43.20 Copy Malignant melanoma of unspecified ear and external auricular canal
C43.21 Copy Malignant melanoma of right ear and external auricular canal
C43.22 Copy Malignant melanoma of left ear and external auricular canal
C43.3 Copy Malignant melanoma of other and unspecified parts of face
C43.30 Copy Malignant melanoma of unspecified part of face
C43.31 Copy Malignant melanoma of nose
C43.39 Copy Malignant melanoma of other parts of face
C43.4 Copy Malignant melanoma of scalp and neck
C43.5 Copy Malignant melanoma of trunk
C43.51 Copy Malignant melanoma of anal skin
C43.52 Copy Malignant melanoma of skin of breast
C43.59 Copy Malignant melanoma of other part of trunk
C43.6 Copy Malignant melanoma of upper limb, including shoulder
C43.60 Copy Malignant melanoma of unspecified upper limb, including shoulder
C43.61 Copy Malignant melanoma of right upper limb, including shoulder
C43.62 Copy Malignant melanoma of left upper limb, including shoulder
C43.7 Copy Malignant melanoma of lower limb, including hip
C43.70 Copy Malignant melanoma of unspecified lower limb, including hip
C43.71 Copy Malignant melanoma of right lower limb, including hip
C43.72 Copy Malignant melanoma of left lower limb, including hip
C43.8 Copy Malignant melanoma of overlapping sites of skin
C43.9 Copy Malignant melanoma of skin, unspecified
C51 Copy Malignant neoplasm of vulva
C51.0 Copy Malignant neoplasm of labium majus
C51.1 Copy Malignant neoplasm of labium minus
C51.2 Copy Malignant neoplasm of clitoris
C51.9 Copy Malignant neoplasm of vulva, unspecified
C52 Copy Malignant neoplasm of vagina
C57 Copy Malignant neoplasm of other and unspecified female genital organs
C57.7 Copy Malignant neoplasm of other specified female genital organs
C57.8 Copy Malignant neoplasm of overlapping sites of female genital organs
C57.9 Copy Malignant neoplasm of female genital organ, unspecified
C60 Copy Malignant neoplasm of penis
C60.0 Copy Malignant neoplasm of prepuce
C60.1 Copy Malignant neoplasm of glans penis
C60.8 Copy Malignant neoplasm of overlapping sites of penis
C60.9 Copy Malignant neoplasm of penis, unspecified
C63 Copy Malignant neoplasm of other and unspecified male genital organs
C63.0 Copy Malignant neoplasm of epididymis
C63.00 Copy Malignant neoplasm of unspecified epididymis
C63.01 Copy Malignant neoplasm of right epididymis
C63.02 Copy Malignant neoplasm of left epididymis
C63.1 Copy Malignant neoplasm of spermatic cord
C63.10 Copy Malignant neoplasm of unspecified spermatic cord
C63.11 Copy Malignant neoplasm of right spermatic cord
C63.12 Copy Malignant neoplasm of left spermatic cord
C63.2 Copy Malignant neoplasm of scrotum
C63.7 Copy Malignant neoplasm of other specified male genital organs
C63.8 Copy Malignant neoplasm of overlapping sites of male genital organs
C63.9 Copy Malignant neoplasm of male genital organ, unspecified

International Classification of Diseases, Tenth Revision, Clinical Modification Diagnosis Codes (ICD-10-CM)7

C33 Copy Malignant neoplasm of trachea
C34 Copy Malignant neoplasm of bronchus and lung
C34.0 Copy Malignant neoplasm of main bronchus, carina, and hilus (of lung)
C34.00 Copy Malignant neoplasm of unspecified main bronchus
C34.01 Copy Malignant neoplasm of right main bronchus
C34.02 Copy Malignant neoplasm of left main bronchus
C34.1 Copy Malignant neoplasm of upper lobe, bronchus or lung
C34.10 Copy Malignant neoplasm of upper lobe, unspecified bronchus or lung
C34.11 Copy Malignant neoplasm of upper lobe, right bronchus or lung
C34.12 Copy Malignant neoplasm of upper lobe, left bronchus or lung
C34.2 Copy Malignant neoplasm of middle lobe, bronchus or lung
C34.3 Copy Malignant neoplasm of lower lobe, bronchus or lung
C34.30 Copy Malignant neoplasm of lower lobe, unspecified bronchus or lung
C34.31 Copy Malignant neoplasm of lower lobe, right bronchus or lung
C34.32 Copy Malignant neoplasm of lower lobe, left bronchus or lung
C34.8 Copy Malignant neoplasm of overlapping sites of bronchus and lung
C34.80 Copy Malignant neoplasm of overlapping sites of unspecified bronchus and lung
C34.81 Copy Malignant neoplasm of overlapping sites of right bronchus and lung
C34.82 Copy Malignant neoplasm of overlapping sites of left bronchus and lung
C34.9 Copy Malignant neoplasm of unspecified part of bronchus or lung
C34.90 Copy Malignant neoplasm of unspecified part of unspecified bronchus or lung
C34.91 Copy Malignant neoplasm of unspecified part of right bronchus or lung
C34.92 Copy Malignant neoplasm of unspecified part of left bronchus or lung

International Classification of Diseases, Tenth Revision, Clinical Modification Diagnosis Codes (ICD-10-CM)7

C64 Copy Malignant neoplasm of kidney, except renal pelvis
C64.1 Copy Malignant neoplasm of right kidney, except renal pelvis
C64.2 Copy Malignant neoplasm of left kidney, except renal pelvis
C64.9 Copy Malignant neoplasm of unspecified kidney, except renal pelvis
C65 Copy Malignant neoplasm of renal pelvis
C65.1 Copy Malignant neoplasm of right renal pelvis
C65.2 Copy Malignant neoplasm of left renal pelvis
C65.9 Copy Malignant neoplasm of unspecified renal pelvis

International Classification of Diseases, Tenth Revision, Clinical Modification Diagnosis Codes (ICD-10-CM)7

C00 Copy Malignant neoplasm of lip
C00.0 Copy Malignant neoplasm of external upper lip
C00.1 Copy Malignant neoplasm of external lower lip
C00.2 Copy Malignant neoplasm of external lip, unspecified
C00.3 Copy Malignant neoplasm of upper lip, inner aspect
C00.4 Copy Malignant neoplasm of lower lip, inner aspect
C00.5 Copy Malignant neoplasm of lip, unspecified, inner aspect
C00.6 Copy Malignant neoplasm of commissure of lip, unspecified
C00.8 Copy Malignant neoplasm of overlapping sites of lip
C00.9 Copy Malignant neoplasm of lip, unspecified
C01 Copy Malignant neoplasm of base of tongue
C02 Copy Malignant neoplasm of other and unspecified parts of tongue
C02.0 Copy Malignant neoplasm of dorsal surface of tongue
C02.1 Copy Malignant neoplasm of border of tongue
C02.2 Copy Malignant neoplasm of ventral surface of tongue
C02.3 Copy Malignant neoplasm of anterior two-thirds of tongue, part unspecified
C02.4 Copy Malignant neoplasm of lingual tonsil
C02.8 Copy Malignant neoplasm of overlapping sites of tongue
C02.9 Copy Malignant neoplasm of tongue, unspecified
C03 Copy Malignant neoplasm of gum
C03.0 Copy Malignant neoplasm of upper gum
C03.1 Copy Malignant neoplasm of lower gum
C03.9 Copy Malignant neoplasm of gum, unspecified
C04 Copy Malignant neoplasm of floor of mouth
C04.0 Copy Malignant neoplasm of anterior floor of mouth
C04.1 Copy Malignant neoplasm of lateral floor of mouth
C04.8 Copy Malignant neoplasm of overlapping sites of floor of mouth
C04.9 Copy Malignant neoplasm of floor of mouth, unspecified
C05 Copy Malignant neoplasm of palate
C05.0 Copy Malignant neoplasm of hard palate
C05.1 Copy Malignant neoplasm of soft palate
C05.2 Copy Malignant neoplasm of uvula
C05.8 Copy Malignant neoplasm of overlapping sites of palate
C05.9 Copy Malignant neoplasm of palate, unspecified
C06 Copy Malignant neoplasm of other and unspecified parts of mouth
C06.0 Copy Malignant neoplasm of cheek mucosa
C06.1 Copy Malignant neoplasm of vestibule of mouth
C06.2 Copy Malignant neoplasm of retromolar area
C06.8 Copy Malignant neoplasm of overlapping sites of other and unspecified parts of mouth
C06.80 Copy Malignant neoplasm of overlapping sites of unspecified parts of mouth
C06.89 Copy Malignant neoplasm of overlapping sites of other parts of mouth
C06.9 Copy Malignant neoplasm of mouth, unspecified
C09 Copy Malignant neoplasm of tonsil
C09.0 Copy Malignant neoplasm of tonsillar fossa
C09.1 Copy Malignant neoplasm of tonsillar pillar (anterior) (posterior)
C09.8 Copy Malignant neoplasm of overlapping sites of tonsil
C09.9 Copy Malignant neoplasm of tonsil, unspecified
C10 Copy Malignant neoplasm of oropharynx
C10.0 Copy Malignant neoplasm of vallecula
C10.1 Copy Malignant neoplasm of anterior surface of epiglottis
C10.2 Copy Malignant neoplasm of lateral wall of oropharynx
C10.3 Copy Malignant neoplasm of posterior wall of oropharynx
C10.4 Copy Malignant neoplasm of branchial cleft
C10.8 Copy Malignant neoplasm of overlapping sites of oropharynx
C12 Copy Malignant neoplasm of pyriform sinus
C13 Copy Malignant neoplasm of hypopharynx
C13.0 Copy Malignant neoplasm of postcricoid region
C13.1 Copy Malignant neoplasm aryepiglottic fold, hypopharyngeal aspect
C13.2 Copy Malignant neoplasm of posterior wall of hypopharynx
C13.8 Copy Malignant neoplasm of overlapping sites of hypopharynx
C13.9 Copy Malignant neoplasm of hypopharynx, unspecified
C14 Copy Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
C14.0 Copy Malignant neoplasm of pharynx, unspecified
C14.2 Copy Malignant neoplasm of Waldeyer’s ring
C14.8 Copy Malignant neoplasm of overlapping sites of lip, oral cavity and pharynx
C32 Copy Malignant neoplasm of larynx
C32.0 Copy Malignant neoplasm of glottis
C32.1 Copy Malignant neoplasm of supraglottis
C32.2 Copy Malignant neoplasm of subglottis
C32.3 Copy Malignant neoplasm of laryngeal cartilage
C32.8 Copy Malignant neoplasm of overlapping sites of larynx
C32.9 Copy Malignant neoplasm of larynx, unspecified
C76 Copy Malignant neoplasm of other and ill-defined sites
C76.0 Copy Malignant neoplasm of head, face and neck

International Classification of Diseases, Tenth Revision, Clinical Modification Diagnosis Codes (ICD-10-CM)7

C65 Copy Malignant neoplasm of renal pelvis
C65.1 Copy Malignant neoplasm of right renal pelvis
C65.2 Copy Malignant neoplasm of left renal pelvis
C65.9 Copy Malignant neoplasm of unspecified renal pelvis
C66 Copy Malignant neoplasm of ureter
C66.1 Copy Malignant neoplasm of right ureter
C66.2 Copy Malignant neoplasm of left ureter
C66.9 Copy Malignant neoplasm of unspecified ureter
C67 Copy Malignant neoplasm of bladder
C67.0 Copy Malignant neoplasm of trigone of bladder
C67.1 Copy Malignant neoplasm of dome of bladder
C67.2 Copy Malignant neoplasm of lateral wall of bladder
C67.3 Copy Malignant neoplasm of anterior wall of bladder
C67.4 Copy Malignant neoplasm of posterior wall of bladder
C67.5 Copy Malignant neoplasm of bladder neck
C67.6 Copy Malignant neoplasm of ureteric orifice
C67.8 Copy Malignant neoplasm of overlapping sites of bladder
C67.9 Copy Malignant neoplasm of bladder, unspecified
C68 Copy Malignant neoplasm of other and unspecified urinary organs
C68.0 Copy Malignant neoplasm of urethra
C68.8 Copy Malignant neoplasm of overlapping sites of urinary organs
C68.9 Copy Malignant neoplasm of urinary organ, unspecified

Coding for OPDIVO QVANTIG is dependent on the insurer and the care setting in which the drug will be administered. Oncology practices need to make coding decisions based on the diagnosis and treatment of each patient and the specific insurer requirements.

Please see U.S. Full Prescribing Information for OPDIVO QVANTIG.

*Healthcare providers should code healthcare claims based upon the service that is rendered, the patient's medical record, the coding requirements of each health insurer, and best coding practices. Coding information provided under this heading does not provide a guarantee of reimbursement and should be considered together with all applicable coding guidance and standards. All of the coding information presented by this website is applicable to outpatient procedures only.

CPT codes and descriptions only are ©2024 by American Medical Association (AMA). All rights reserved. The AMA assumes no liability for data contained or not contained herein. CPT is a registered trademark of the American Medical Association.

This is a category code and is invalid for stand-alone use. Please select one of the expanded codes listed below.

References:

  1. American Medical Association. 2020 HCPCS Level II. Professional ed. Chicago, IL: American Medical Association; 2020.
  2. Centers for Medicare & Medicaid Services. MLN Matters, Number MM9603 Revised. https://www.cms.gov/Outreach-and-Education/Medicare-Learning-Network-MLN/MLNMattersArticles/Downloads/MM9603.pdf. Revised June 10, 2016. Accessed September 12, 2024.
  3. Centers for Medicare & Medicaid Services. Calendar year (CY) 2023 Medicare physician fee schedule final rule. https://www.cms.gov/newsroom/fact-sheets/calendar-year-cy-2023-medicare-physician-fee-schedule-final-rule. Accessed September 12, 2024.
  4. National Uniform Billing Committee (NUBC). Official UB-04 Data Specifications Manual 2020. Chicago, IL: American Hospital Association; 2020. Accessed September 12, 2024.
  5. American Medical Association. CPT Professional 2020. Professional ed. Chicago, IL: American Medical Association; 2019.
  6. OPDIVO QVANTIG [package insert]. Princeton, NJ: Bristol-Myers Squibb Company.
  7. Centers for Medicare & Medicaid Services. ICD-10-CM tabular list of diseases and injuries. https://www.cms.gov/medicare/coding-billing/icd-10-codes/2024-icd-10-cm. Accessed September 12, 2024.

The accurate completion of reimbursement- or coverage-related documentation is the responsibility of the healthcare provider and patient. Bristol Myers Squibb and its agents make no guarantee regarding reimbursement for any service or item.

Select Your Patient’s Condition

OPDIVO QVANTIG may be purchased through the distributors listed below.

Physician Offices

Authorized Distributor Phone Orders Fax Orders and Website
Besse Medical 1‑877‑711‑5469 https://www.besse.com
Cardinal Health Specialty Pharmaceutical Distribution 1‑877‑453‑3972
Monday-Friday
(24-hour emergency on call)
https://specialtyonline.cardinalhealth.com
CuraScript Specialty Distribution 1‑877‑599‑7748
Monday-Friday
https://www.curascriptsd.com
HyGen Pharmaceuticals Specialty Division 1‑877‑630‑9198
Monday-Friday
https://www.hygenpharma.com/#contactus
McKesson Specialty Health 1‑800‑482‑6700
Monday-Friday
https://mscs.mckesson.com
Morris & Dickson Specialty 1‑800‑710‑6100
Monday-Friday
Fax: 1‑318‑524‑3096
https://www.mdspecialtydist.com
Oncology Supply 1‑800‑633‑7555 https://www.oncologysupply.com

For offices that prefer to use the services of a specialty pharmacy, specialty pharmacies can obtain OPDIVO QVANTIG from the distributors listed above.

Hospitals and Infusion Centers

Authorized Distributor Phone Orders Fax Orders and Website
ASD Healthcare 1‑800‑746‑6273
Monday-Friday
Fax: 1‑800‑547‑9413
https://www.asdhealthcare.com
Cardinal Health Specialty Pharmaceutical Distribution 1‑866‑677‑4844
Monday-Friday
(24-hour emergency on call)
Fax: 1‑614‑553‑6301
https://orderexpress.cardinalhealth.com
DMS Pharmaceutical Group, Inc. 1‑877‑788‑1100 Fax: 1‑847‑518‑1105
www.dmspharma.com
HyGen Pharmaceuticals Specialty Division 1‑877‑630‑9198
Monday-Friday
https://www.hygenpharma.com/#contactus
McKesson Plasma and Biologics 1‑877‑625‑2566
Monday-Friday
Fax: 1‑888‑752‑7626
https://connect.mckesson.com
Morris & Dickson Specialty 1‑800‑710‑6100
Monday-Friday
Fax: 1‑318‑524‑3096
https://www.mdspecialtydist.com

Puerto Rico Hospitals and Clinics

Authorized Distributor Phone Orders Fax Orders and Website
Amerisource
Bergen Puerto Rico
1‑844‑222‑2273 https://abcorder.amerisourcebergen.com

Above information is accurate as of 11/24.

The OPDIVO QVANTIG distribution program includes extended payment terms to Bristol Myers Squibb authorized OPDIVO QVANTIG distributors. Healthcare providers and institutions should contact their OPDIVO QVANTIG distributor to understand specific payment terms that may be available to them from their distributor.

Please see U.S. Full Prescribing Information for OPDIVO QVANTIG.

Select Your Patient’s Condition

FDA Approval Letter as Posted by the FDA:

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OPDIVO QVANTIG is indicated for:

  • adult patients with MSI-H or dMMR metastatic CRC that has progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan, as monotherapy or as monotherapy following combination treatment with intravenous nivolumab and ipilimumab – Approved on 12/27/2024
    Limitations of Use: OPDIVO QVANTIG is not indicated in combination with ipilimumab for the treatment of MSI-H or dMMR metastatic CRC.
View Letter
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OPDIVO QVANTIG is indicated for:

  • adult patients with completely resected esophageal or gastroesophageal junction cancer with residual pathologic disease, who have received neoadjuvant chemoradiotherapy (CRT)
  • adult patients with unresectable advanced or metastatic esophageal squamous cell carcinoma as first-line treatment in combination with fluoropyrimidine- and platinum-containing chemotherapy
    Limitations of Use: OPDIVO QVANTIG is not indicated in combination with ipilimumab for the treatment of patients with unresectable advanced or metastatic ESCC
  • adult patients with unresectable advanced, recurrent or metastatic esophageal squamous cell carcinoma (ESCC) after prior fluoropyrimidine- and platinum-based chemotherapy – Approved on 12/27/2024
View Letter
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OPDIVO QVANTIG is indicated for:

  • adult patients with advanced or metastatic gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma in combination with fluoropyrimidine- and platinum-containing chemotherapy – Approved on 12/27/2024
View Letter
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OPDIVO QVANTIG is indicated for:

  • adult patients with HCC previously treated with sorafenib and following combination treatment with intravenous nivolumab and ipilimumab – Approved on 12/27/2024
    Limitations of Use: OPDIVO QVANTIG is not indicated in combination with ipilimumab for the treatment of HCC.
View Letter
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OPDIVO QVANTIG is indicated for:

  • adult patients with unresectable or metastatic melanoma
  • adult patients with unresectable or metastatic melanoma following combination treatment with intravenous nivolumab and ipilimumab
    Limitations of Use: OPDIVO QVANTIG is not indicated in combination with ipilimumab for the treatment of unresectable or metastatic melanoma.
  • the adjuvant treatment of adult patients with completely resected Stage IIB, Stage IIC, Stage III, or Stage IV melanoma – Approved on 12/27/2024
View Letter
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OPDIVO QVANTIG is indicated for:

  • adult patients with resectable (tumors ≥4 cm or node positive) NSCLC in the neoadjuvant setting, in combination with platinum-doublet chemotherapy
  • adult patients with metastatic NSCLC and progression on or after platinum-based chemotherapy. Patients with EGFR or ALK genomic tumor aberrations should have disease progression on FDA-approved therapy for these aberrations prior to receiving OPDIVO QVANTIG
    Limitations of Use: OPDIVO QVANTIG is not indicated in combination with ipilimumab for the treatment of metastatic NSCLC.
  • adult patients with resectable (tumors ≥4 cm or node positive) NSCLC and no known EGFR mutations or ALK rearrangements, for neoadjuvant treatment, in combination with platinum-doublet chemotherapy, followed by OPDIVO QVANTIG monotherapy as adjuvant treatment after surgery – Approved on 12/27/2024
View Letter
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OPDIVO QVANTIG is indicated for:

  • adult patients with intermediate or poor risk advanced RCC, as a first-line treatment following combination treatment with intravenous nivolumab and ipilimumab
    Limitations of Use: OPDIVO QVANTIG is not indicated in combination with ipilimumab for the treatment of renal cell carcinoma.
  • adult patients with advanced RCC, as a first-line treatment in combination with cabozantinib
  • adult patients with advanced RCC who have received prior anti-angiogenic therapy – Approved on 12/27/2024
View Letter
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OPDIVO QVANTIG is indicated for:

  • adult patients with recurrent or metastatic SCCHN with disease progression on or after a platinum-based therapy – Approved on 12/27/2024
View Letter
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OPDIVO QVANTIG is indicated for:

  • adjuvant treatment of adult patients with UC who are at high risk of recurrence after undergoing radical resection of UC
  • adult patients with unresectable or metastatic urothelial carcinoma, as first-line treatment in combination with cisplatin and gemcitabine
  • adult patients with locally advanced or metastatic UC who:
    • have disease progression during or following platinum-containing chemotherapy
    • have disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy – Approved on 12/27/2024
View Letter

Please see U.S. Full Prescribing Information for OPDIVO QVANTIG for complete indications.

Claim Forms for Outpatient Administration – Tutorial

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CMS-1500
Hospital Outpatient
UB-04/CMS-1450
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